HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → Ethyl 2-(5-bromomethyl-2-pyridinyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 2-(5-methyl-2-pyridinyl)benzoate | HCID 19976479 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 2-(5-bromomethyl-2-pyridinyl)benzoate | HCID 19976701 | — |
Reaction Steps
Under nitrogen, the crude ethyl 2-(5-methyl-2-pyridinyl)benzoate from step 6 was treated with 1.7 g (9.5 mmol) of NBS and 160 mg (0.66 mmol) of benzoyl peroxide in 145 mL of anhydrous carbon tetrachloride at reflux for 2.5 h. The reaction was filtered under nitrogen and concentrated in vacuo to give crude ethyl 2-(5-bromomethyl-2-pyridinyl)benzoate; no purification was attempted.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602153 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-c4dfed6e610046cea04f427040f34646 |
| Source note | uspto-grants-1997_02 |