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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1450596Generated: October 29, 2026

tert.butyl 4'-[[2-n-propyl-4-methyl-6-(4-isopropyl-5-methyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate → 4'-[[2-n-Propyl-4-methyl-6-(1-isopropyl-4-isopropyl-5-methyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid

https://huagongshe.com/reaction/1450596

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert.butyl 4'-[[2-n-propyl-4-methyl-6-(4-isopropyl-5-methyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylateHCID 67708445—
ReactantN-isopropylformamide isopropylamineHCID 86750142—
Product4'-[[2-n-Propyl-4-methyl-6-(1-isopropyl-4-isopropyl-5-methyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acidHCID 54536499—

Reaction Steps

Prepared analogously to Example 146 from tert.butyl 4'-[[2-n-propyl-4-methyl-6-(4-isopropyl-5-methyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and N-isopropylformamide/isopropylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05602127
Source datasetuspto-grants-1997_02
ORD IDord-2a86dd718f56461a8f49f438ca2a43bc
Source noteuspto-grants-1997_02