HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-Phenyl-5-{2-(1-pyrrolidinylmethyl)-3-methylbutyryl}isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| Reactant | 3-Phenyl-5-(3-methylbutyryl)isoxazole | HCID 15180767 | — |
| Product | 3-Phenyl-5-{2-(1-pyrrolidinylmethyl)-3-methylbutyryl}isoxazole | HCID 19976918 | — |
Reaction Steps
From 1.5 g (6.6 mmol) of 3 -phenyl-5-(3-methylbutyryl)isoxazole prepared above in the procedure (2), 0.84 g (7.9 mmol) of piperidine hydrochloride, and 0.26 g (8.7 mmol) of paraformaldehyde, the free base of 3-phenyl-5-{2-(1-pyrrolidinylmethyl)-3-methylbutyryl}isoxazole was obtained as crystals in a manner similar to Example 28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602160 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-0c12c02f94ff4d69a47e32809d0c89d9 |
| Source note | uspto-grants-1997_02 |