Chloroform → 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline

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Reaction Steps

A solution of 2-chloro-N4 -(2-methylpropyl)-3,4-quinolinediamine (3 g) in triethylorthoformate (2.8 g) was heated at 80° C. for 15 h. The resulting solution was cooled to ambient temperature and 20 mL of chloroform was added. The solution was washed with water. The product 4-chloro-1-(2-methylpropyl)-1H-imidazo[4.5-c]-quinoline was obtained by concentrating the solution.

Provenance & Evidence