HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1450695Generated: November 3, 2026
O-Xylene → 4-chloro-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
https://huagongshe.com/reaction/1450695
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 1-((3-Amino-2-chloroquinolin-4-yl)amino)-2-methylpropan-2-ol | HCID 22672654 | — |
| Solvent | Ethyl orthoformate | HCID 31214 | — |
| Product | 4-chloro-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol | HCID 9838458 | — |
Reaction Steps
A suspension of 1-[(3-amino-2-chloro-4-quinolinyl)amino]-2-methyl-2-propanol (5 g from EXAMPLE 13) in xylene (50 mL) and triethylorthoformate (5 mL) was heated at 80° C. until no starting material remained as determined by thin layer chromatography. The resulting solution was cooled, and the precipitated product was isolated by filtration and washed with xylene (3×10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05602256 |
|---|
| Source dataset | uspto-grants-1997_02 |
|---|
| ORD ID | ord-c37e6987a914493496880c716c0cbecc |
|---|
| Source note | uspto-grants-1997_02 |
|---|
