HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-5-nitropyrimidine → 9-Ethyl-4-[(2-(phenylmethoxy)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Ethylimidazole | HCID 66130 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | N-Methyl-2-benzyloxyethylamine | HCID 268107 | — |
| Product | 9-Ethyl-4-[(2-(phenylmethoxy)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 9951703 | — |
Reaction Steps
Prepared by treatment of N-(2-(phenylmethoxy)ethyl)methylamine with 4,6-dichloro-5-nitropyrimidine, followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride, and cyclization with carbonyldiimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602252 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-7f12d1f90d1a4448a74e0dbc0f9e2713 |
| Source note | uspto-grants-1997_02 |