Methanol → 9-Ethyl-4-[(2-hydroxyethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
Reaction equation
[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:28])[NH:8][C:9]3[C:10]([N:16]([CH2:18][CH2:19][O:20]CC4C=CC=CC=4)[CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2].CO.[OH-].[Na+]>[Pd]>[CH2:1]([C:3]1[N:15]2[C:6]([C:7](=[O:28])[NH:8][C:9]3[C:10]([N:16]([CH2:18][CH2:19][OH:20])[CH3:17])=[N:11][CH:12]=[N:13][C:14]=32)=[CH:5][N:4]=1)[CH3:2]Participants
5
Procedure
Prepared by hydrogenation of the product of Example 24 with palladium on carbon in methanol containing 1.1 eq. NaOH at 50 psi for 8 hr.
Sources & evidence
- ORD record
- ord-6395a218209d4c56a180dc71d15ddd6c
- Source dataset
- uspto-grants-1997_02
- Patent number
- US05602252
Reaction notes
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