HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 9-Ethyl-4-[(2-hydroxyethyl)amino]-7-methylimidazo[5,1-h]-pteridin6(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-Benzylamino-2-benzyloxyethane | HCID 562448 | — |
| Reactant | HCID 178437635 | HCID 178437635 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 9-Ethyl-4-[(2-hydroxyethyl)amino]-7-methylimidazo[5,1-h]-pteridin6(5H)-one | HCID 56623211 | — |
Reaction Steps
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-(2(benzyloxy)ethyl)benzylamine, followed by reaction with 2-ethyl-4-methylimidazole, reduction with tin (II) chloride, cyclization with carbonyldiimidazole, and hydrogenation with palladium on carbon in methanol containing 1.1 eq. NaOH at 50 psi and 50° C. for 24 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602252 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-0af4e02a681c4d708552ed8ebbc56cb4 |
| Source note | uspto-grants-1997_02 |