Benzoic acid, 3-amino-, methyl ester → HCID 178497936, compound

Participants

Reaction Steps

To sodium dicyanamide in 5 mL of deionized water was added dropwise a solution of methyl 3-aminobenzoate (Aldrich, 1.30 g, 8.6 mmol) in 15 mL of 1N HCl. The resulting clear solution was heated at 80°-90° C. for 2 h. The precipitate was collected through filtration, crystallized from chloroform-methanol, dried in air followed by drying in a pistol at acetone reflux in vacuo to give 1.84 g (quantitative) of methyl 3-[amino(cyanoiminomethyl)]aminobenzoate as a white solid, mp 203°-204° C.

Provenance & Evidence