反应详情

A mixture of methyl 3-aminomethylbenzoate hydrochloride (2.014 g, 0.0098 mol) in 1N sodium hydroxide (25 mL, 0.025 mol) was stirred at room temperature for 4 h. The mixture was neutralized with Dowex-H+ resin. The mixture was filtered and acetone (400 mL) was added to the filtrate. The white precipitate was collected by filtration and recrystallized from water-acetone to give 0.80 g of the title compound as a white powder, mp 278°-280° C.

1. filtrationThe mixture was filtered
2. additionacetone (400 mL) was added to the filtrate
3. filtrationThe white precipitate was collected by filtration
4. customrecrystallized from water-acetone