Acetic Acid → HCID 10586568, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl-4-acetylaminobenzoate (Coneglio, L. Rend Acad. Sci. Napoli [3] 1931, 36, 56-60) (2.07 g, 0.01 mol) and palladium acetate (1.12 g, 0.005 mol) in dry toluene (17 mL) was heated at reflux for 0.75 h under nitrogen. The solution was cooled to 60° C., the toluene was decanted, and the residue was washed with fresh toluene. The combined filtrates were heated at reflux for 3 h, the precipitate was collected by filtration, and mixed with the previous residue. The combined greenish residues were dried under vacuum for 3 h. To this residue, glacial acetic acid (40 mL) and allyl iodide (8.40 g, 0.05 mol) were added and the mixture was stirred at room temperature for 16 h. The palladium was removed by filtration through Celite and the filtrate was concentrated. The residue was passed through a column of silica gel using 1:1 ethyl acetate:hexane as eluent to give 0.85 g (69%) of ethyl-4-acetylamino-3-allylbenzoate as a white powder, mp 127°-128° C.

Provenance & Evidence