Sodium Hydroxide → HCID 67717582, compound

HRID 1451093Notes

Reaction equation

HRID 1451093 reaction equation
Cl.[C:2]([NH:5][C:6]1[C:7](=[CH:16][NH:17][NH:18][CH:19]=[N:20][NH2:21])[CH2:8][C:9](=[CH:14][CH:15]=1)[C:10]([O:12]C)=[O:11])(=[O:4])[CH3:3].[OH-:22].[Na+]>>[OH2:4].[OH2:22].[C:2]([NH:5][C:6]1[C:7](=[CH:16][NH:17][NH:18][CH:19]=[N:20][NH2:21])[CH2:8][C:9](=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 67717228HCID 67717228, compound

Product 1

HCID 67717582HCID 67717582, compoundYield 160.1%

Procedure

A mixture of methyl 4-acetylamino-3-{[(aminoiminomethyl)hydrazino]methylene}benzoate hydrochloride (0.54 g, 0.0017 mol) and 1N sodium hydroxide (5.0 mL, 0.005 mol) was stirred at room temperature for 24 h. After filtration, the mixture was neutralized with concentrated hydrochloric acid. The precipitate was collected by filtration, washed with water, and dried over toluene under vacuum to give 0.41 g (80%) of the title compound as a white powder, mp 326°-327° C.

Workup

  1. filtrationAfter filtration
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. dry with materialdried over toluene under vacuum

Sources & evidence

ORD record
ord-605e204a600b4d7d859905ae32146e26
Source dataset
uspto-grants-1997_02
Patent number
US05602277

Reaction notes

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