Nitric Acid → HCID 10613312, compound

Participants

Reaction Steps

Ethyl 4-[(methylsulfonyl)amino]benzoate (Lumma, W. C. et al. J. Med. Chem. 1987, 30, 758-763) (2.0 g, 0.0082 mol) was added portionwise to fuming nitric acid (10 mL) at 5°-10° C. over 0.25 h. The mixture was further stirred for 0.5 h at 10°-15° C. and then poured into cold water (50 mL). The yellow precipitate was separated by filtration and washed several times with cold water. The cake was recrystallized from ethyl acetate to give 1.7 g (72%) of ethyl 3-nitro-4-[(methylsulfonyl)amino]benzoate as yellow crystals, mp 124° C.

Provenance & Evidence