Hydroxyamine hydrochloride → HCID 85281006, compound

Participants

Reaction Steps

A mixture of 2-(methanesulfonylamino)-5-(methoxycarbonyl)benzaldehyde (2.56 g, 0.01 mol) and hydroxylamine hydrochloride (0.87 g, 0.0125 mol) in ethanol (40 mL) was heated at reflux for 2 h. The mixture was filtered hot, and the filtrate was concentrated to dryness. The residue was suspended in water. The solid was collected by filtration and recrystallized from ethyl acetate-hexane to give 2.42 g (89%) of methyl 3-[(N-hydroxyimino)methyl]-4-[(methylsulfonyl)amino]benzoate as an off-white powder, mp 160° C.

Provenance & Evidence