HCID 19977470, compound → HCID 19977492, compound

Participants

Reaction Steps

Methyl 3-formyl-4-[(methylsulfonyl)amino]-5-nitrobenzoate (2.0 g, 0.0066 mol) was dissolved in ethanol (50 mL) and hydrogenated at 30 psi in the presence of platinum oxide (Aldrich, 0.1 g) for 4 h. The catalyst was removed by filtration through Celite and the filtrate was concentrated to dryness. The residue was recrystallized from methanolethyl acetate-hexane to give 0.8 g (44%) of methyl 3-amino-5-hydroxymethyl-4-[(methylsulfonyl)amino]benzoate as a light brown powder, mp 150°-155° C.

Provenance & Evidence