HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 4-Methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Isovanillin | HCID 12127 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Methoxybenzaldehyde | HCID 31244 | — |
Reaction Steps
Namely, (R)-(+)-endo-2-norborneol (2) in tetrahydrofuran is reacted under reflux with 3-hydroxy-4-methoxybenzaldehyde in the presence of diethyl azodicarboxlate and triphenyl phosphine to obtain 3-[(2S)-exo-bicyclo[2.2.1]hepto-2-yloxy]-4-methoxybenzaldehyde (6), then via three steps (as shown in EPO 428 313 A), and the pyrimidone derivative (9) is derived.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604120 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-225b07b408304336bd47a22d649a6345 |
| Source note | uspto-grants-1997_02 |