2-Chlorobenzoyl chloride → HCID 19973948, compound

Participants

Reaction Steps

2-Chlorobenzoyl chloride (0.35 g) in ethyl acetate (3 ml) was added to a stirred solution of ethyl 2-amino-3-methyl-2-(4,6-dimethoxypyrimidin-2-yl)butanoate (0.566 g) and ethyl diisopropylamine (0.258 g) in ethyl acetate (15 ml). The mixture was stirred at room temperature for 2 hours, filtered, and the filtrate was washed with water, dried and evaporated to dryness under vacuum. The residual solid was triturated with 60°-80° petroleum ether to give 0.4 g of the desired product as a white solid, mp 94°-95° C.

Provenance & Evidence