反应详情

2-Chloro-2-(4,6-dimethoxypyrimidin-2-yl)-N-methanesulfonyl-2-phenylacetamide (0.7 g) was boiled under reflux with sodium methoxide (0.2 g) in methanol (30 ml) for 5 hours. The methanol was evaporated off under vacuum. The residue was treated with ether and the precipitated sodium salt was taken into water. The aqueous solution was washed with ether, fresh ether was added, and the whole was acidified with hydrochloric acid. A white solid crystallised from the ether layer. This was filtered off, washed with water and a little ether, and dried to give 0.47 g of the desired product, mp 155°-7° C.

1. customThe methanol was evaporated off under vacuum
2. additionThe residue was treated with ether
3. washThe aqueous solution was washed with ether, fresh ether
4. additionwas added
5. customA white solid crystallised from the ether layer
6. filtrationThis was filtered off
7. washwashed with water
8. dry with materiala little ether, and dried