反应详情

After 0.3 g of 4,5-dichloro-6-[3-(phenylthio)propyloxy]-3(2H)-pyridazinone and 0.243 g of 3-picolylamine were dissolved in a solvent mixture of water-dioxane (1:1), the mixture was heated to reflux for 8 hours. After completion of the reaction, the reaction mixture was poured onto water and extracted with ethyl acetate. After washing with water and drying, the solvent was distilled off. The resulting crystals were recrystallized from isopropanol to give 0.273 g of the objective compound. Yield, 73%, Melting point, 152°-155° C.

1. temperaturethe mixture was heated
2. temperatureto reflux for 8 hours
3. customAfter completion of the reaction
4. additionthe reaction mixture was poured onto water
5. extractionextracted with ethyl acetate
6. washAfter washing with water
7. customdrying
8. distillationthe solvent was distilled off
9. customThe resulting crystals were recrystallized from isopropanol