Sodium Thiosulfate → HCID 19974388, compound

Participants

Reaction Steps

To a solution of 0.4 g of 4-bromo-6-[2-(2-chlorophenylthio)ethyloxy]-5-(3,4-dimethoxyphenylmethylamino)-3(2H)-pyridazinone in 30 ml of dichloromethane was added dropwise a solution of 0.15 g of metachloroperbenzoic acid in 5 ml of dichloromethane at 0° C. The excess peracid was decomposed by the addition of saturated aqueous sodium thiosulfate. The mixture was diluted with dichloromethane, washed with brine, dried over magnesium sulfate and concentrated. The residue was chromatographed on silicagel to give 0.34 g of the objective compound. Yield, 83%, Melting point, 183°-185° C.

Provenance & Evidence