反应详情

温度

65 °C

To a stirred solution of sodium hydroxide (0.06 g, 1.5 mM) in methanol (7 mL) under a nitrogen atmosphere was added 5-methoxy -2H-3,1-benzoxazine-2,4(1H)-dione (2.90 g, 15.0 mM). The reaction mixture was stirred at 65° C. for 14.5 hr, cooled to room temperature and poured into water. The resulting solution was extracted with ethyl acetate and the combined extracts were dried (Na2SO4), filtered and concentrated to provide the title compound (2.55 g, 94%) as a tan oil; MS(CI): 182 (M+H).

1. temperaturecooled to room temperature
2. extractionThe resulting solution was extracted with ethyl acetate
3. dry with materialthe combined extracts were dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated