反应详情

To a suspension of 7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline -1,4-dione (0.600g, 1.95 mM) in methanol (20 mL) was added choline hydroxide (0.24 g, 1.98 mM, 45% solution in methanol). The resulting solution was concentrated and the solid yellow residue was recrystallized from ethanol to provide (0.62 g, 78%) the title compound as yellow crystals, mp 227.5°-228.5° C. Analysis for C11H5BrN3O3 ·C5H14NO·0.6 C5H5OH·0.2 H2O Calculated: C, 46.69; H, 5.24; N, 12.66 Found: C, 46.73; H, 5.33; N, 12.31

1. concentrationThe resulting solution was concentrated
2. customthe solid yellow residue was recrystallized from ethanol