HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-(2,5-Dimethyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14738583 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Bromo-1-(2,5-dimethyloxazol-4-yl)ethanone | HCID 14076232 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2.8 g (0.02 mol) of 2,5-Dimethyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 35% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 100° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 2 hours the solvent is removed, and the residue is triturated with 50 ml of ether and filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604225 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-a62a6b22938e4a25a187b70e52d8bddb |
| Source note | uspto-grants-1997_02 |