Sodium Hydroxide → HCID 14076216, compound

HRID 1451399Notes

Reaction equation

[C:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:31])[C:17]2[N:18]=[C:19]([NH:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[S:20][CH:21]=2)=[CH:8][CH:7]=1)([O:3]CC)=[O:2].[OH-].[Na+]>>[C:1]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][NH:14][CH2:15][CH:16]([OH:31])[C:17]2[N:18]=[C:19]([NH:22][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[S:20][CH:21]=2)=[CH:10][CH:11]=1)([OH:3])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 14076215HCID 14076215, compound

Product 1

HCID 14076216HCID 14076216, compound

Procedure

Prepared analogously to Example 2 by reaction of N-[2-(4-carboethoxyphenyl)ethyl]-2-hydroxy-2-(2-benzoylamino-thiazol-4-yl)ethanamine with 1N sodium hydroxide solution, followed by purification of the crude product on a silica gel column using chloroform/methanol=1:1 and trituration with water/ethanol=9:1.

Workup

customfollowed by purification of the crude product on a silica gel column

Sources & evidence

ORD record: ord-c1257586951342e080e9e501970d9f7e
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05604225

Reaction notes

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