HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2,4-dimethyl-thiazol-5-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one | HCID 12668422 | — |
| Reactant | Methyl 2-[4-(2-aminopropyl)phenoxy]acetate | HCID 14372867 | — |
| Product | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2,4-dimethyl-thiazol-5-yl)ethanamine | HCID 19974107 | — |
Reaction Steps
Prepared analogously to Example 3 by reaction of 2,4-dimethyl-5-bromoacetyl-thiazole with 2-(4-carbomethoxymethoxyphenyl)-1-methylethylamine, followed by reduction and purification of the base on a silica gel column using ethyl acetate/methanol=17:3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604225 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-91cd8f4eccb640f3bf9a7be4111d73e9 |
| Source note | uspto-grants-1997_02 |