反应详情

Prepared analogously to Example 16 by reaction of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl) morpholine in methanol with 1N sodium hydroxide solution. After neutralisation with 1N hydrochloric acid, the mixture is extracted by shaking with methylene chloride, the extract is evaporated to dryness, and the remaining residue is triturated with petroleum ether and filtered off with suction.

1. extractionAfter neutralisation with 1N hydrochloric acid, the mixture is extracted
2. customthe extract is evaporated to dryness
3. customthe remaining residue is triturated with petroleum ether
4. filtrationfiltered off with suction