Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → HCID 19974164, compound

HRID 1451425Notes

Reaction equation

HRID 1451425 reaction equation
[OH:1][CH:2]([C:5]1[N:6]=[C:7]([Cl:10])[S:8][CH:9]=1)[CH2:3][NH2:4].[C:11]([CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24](=O)[CH3:25])=[CH:19][CH:18]=1)([O:13][CH3:14])=[O:12]>>[ClH:10].[C:11]([CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][CH:24]([NH:4][CH2:3][CH:2]([OH:1])[C:5]2[N:6]=[C:7]([Cl:10])[S:8][CH:9]=2)[CH3:25])=[CH:21][CH:22]=1)([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetateHCID 19974374HCID 19974374, compound

Product 1

HCID 19974164HCID 19974164, compound

Procedure

Prepared analogously to Example 13 by reaction of 2-hydroxy-2-(2-chloro-thiazol-4-yl)ethanamine with 1-(4-carbomethoxymethoxyphenyl)-propan-2-one followed by precipitation of the hydrochloride with ethereal hydrochloric acid.

Workup

  1. customfollowed by precipitation of the hydrochloride with ethereal hydrochloric acid

Sources & evidence

ORD record
ord-ad225f7ac46343269ffe409fac3fffe1
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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