4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- → N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Participants

Role	Name	HCID	Charge
Reactant	4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)-	HCID 14076239	—
Reactant	1-[4-(2-Carbomethoxy-1-methylethenyl)phenyl]propan-2-one	HCID 54548003	—
Product	N-[2-(4-(2-Carbomethoxy-1-methylethenyl)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine	HCID 53895654	—

Reaction Steps

Prepared analogously to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-[4-(2-carbomethoxy-1-methylethenyl)phenyl]propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/methanolic ammonia=9.5/0.4/0.1 as eluant.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05604225
Source dataset	uspto-grants-1997_02
ORD ID	ord-cb65ecf225da4a109d36bf9e5a7c92a4
Source note	uspto-grants-1997_02