HCID 10978660, compound → HCID 19974223, compound

HRID 1451434Notes

Reaction equation

HRID 1451434 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9]Br)[N:7]=1.[OH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([NH:24][CH2:25][CH2:26]O)[CH3:23])=[CH:17][CH:16]=1>>[OH:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:21][CH:22]([N:24]2[CH2:25][CH2:26][O:11][CH:8]([C:6]3[N:7]=[C:3]([C:2]([F:13])([F:12])[F:1])[S:4][CH:5]=3)[CH2:9]2)[CH3:23])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 10978660HCID 10978660, compoundHCID 19974211HCID 19974211, compound

Product 1

HCID 19974223HCID 19974223, compound

Procedure

Prepared by analogy to Example 22 by reaction of 2-trifluoromethyl-4-bromoacetyl-thiazole with N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-hydroxyethanamine followed by purification of the base on a silica gel column using chloroform/ethyl acetate=3:1 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-bf559f39d14f4ecfa56f4b79257803ad
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

Loading…