1-(4-Methylaminocarbonylmethoxyphenyl)propan-2-one → N-[2-(4-Methylaminocarbonylmethoxyphenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)morpholine

HRID 1451454Notes

Reaction equation

HRID 1451454 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]2[O:12][CH2:11][CH2:10][NH:9][CH2:8]2)[N:6]=1.[CH3:13][NH:14][C:15]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](=O)[CH3:27])=[CH:21][CH:20]=1)=[O:16]>>[CH3:13][NH:14][C:15]([CH2:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][CH:26]([N:9]2[CH2:10][CH2:11][O:12][CH:7]([C:5]3[N:6]=[C:2]([CH3:1])[S:3][CH:4]=3)[CH2:8]2)[CH3:27])=[CH:23][CH:24]=1)=[O:16]

Participants

3

Reactant 2

HCID 199741571-(4-Methylaminocarbonylmethoxyphenyl)propan-2-oneHCID 199741992-(2-Methyl-1,3-thiazol-4-yl)morpholine

Product 1

HCID 19974274N-[2-(4-Methylaminocarbonylmethoxyphenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)morpholine

Procedure

Prepared by analogy to Example 13 by reaction of 2-(2-methyl-thiazol-4-yl)morpholine with 1-(4-methylaminocarbonylmethoxyphenyl)propan-2-one followed by purification on a silica gel column using ethyl acetate as eluant.

Workup

  1. customfollowed by purification on a silica gel column

Sources & evidence

ORD record
ord-7c3efdfe89254cbc9a4e8d47d7ad1ccf
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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