Ammonia → HCID 19974302, compound

HRID 1451469Notes

Reaction equation

HRID 1451469 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][C:18]([OH:29])([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)(OC)=[O:2].[NH3:30]>>[NH2:30][C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][C:18]([OH:29])([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 14391986HCID 14391986, compound

Product 1

HCID 19974302HCID 19974302, compound

Procedure

2.03 g. (4.76 mmol) of N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)morpholine is dissolved in 20 ml of ammonia-saturated methanol and stirred for 24 hours at ambient temperature. The mixture is then evaporated down and the evaporation residue is purified by column chromatography on silica gel (eluant: ethyl acetate/cyclohexane=3:1).

Workup

  1. customThe mixture is then evaporated down
  2. customthe evaporation residue is purified by column chromatography on silica gel (eluant: ethyl acetate/cyclohexane=3:1)

Sources & evidence

ORD record
ord-b6bb1822e4f046efa57b74b2833d6f16
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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