Hydrochloric Acid → HCID 67713872, compound

Participants

Reaction Steps

The above ester (13.1 g, 31 mmol) was dissolved in ethanol (50 ml), 2N sodium hydroxide (50 ml) was added and the mixture was heated at reflux for 1 h. After cooling to ambient temperature pH was adjusted to 0 with concentrated hydrochloric acid. The resulting mixture was washed with dichloromethane (2×100 ml) and pH in the aqueous phase was adjusted to 2.5 with 1N sodium hydroxide. The mixture was extracted with dichloromethane (100 ml) and the solvent was evaporated from the organic phase in vacuo. To the residue was added acetone (50 ml) and diethylether (50 ml) and the mixture was left for crystallisation. This afforded 5.8 g of the title compound.

Provenance & Evidence