Water → HCID 9803221, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of the ester from Step 4 (5.13 g, 11.5 mmol) in 50 mL of EtOH was added 8N KOH (5 mL, 40 mmol) and 5 mL water. The mixture was heated to 60° C. for 1 h, then cooled and concentrated. The residue was partitioned between 1M HCl and EtOAc. The organic phase was washed with brine, dried over MgSO4, filtered and evaporated. Crystallization from CH2Cl2/ hexanes gave 3.59 g of the title compound.

Provenance & Evidence