Lithium Hydroxide → HCID 19974933, compound

Participants

Reaction Steps

To a room temperature solution of the methyl ester from Step 2 (40 mg, 0.08 mmol) in 3 mL THF and 5 mL MeOH was added 1 mL of 1M LiOH. The resulting solution was stirred 30 h at room temperature, then quenched with aqueous NH4Cl and concentrated in vacuo. The residue was partitioned between 1M HCl and EtOAc, washed with brine, dried over Na2SO4 and evaporated to give 30 mg of the title compound.

Provenance & Evidence