HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(5-methoxy-2-methylindol-3-yl)-4,4,4-trifluoro-2-butenoate → Ethyl 3-(5-methoxy-2-methylindol-3-yl)-4,4,4-trifluorobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(5-methoxy-2-methylindol-3-yl)-4,4,4-trifluoro-2-butenoate | HCID 53700575 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-(5-methoxy-2-methylindol-3-yl)-4,4,4-trifluorobutanoate | HCID 19974941 | 99.8% |
Reaction Steps
A solution of the indole from Step 2 (23 g, 70 mmol) in 200 mL EtOH was treated with 60 psi hydrogen over 5% palladium on carbon (2.3 g) in a Parr shaker for 18 h. The mixture was filtered through celite and evaporated to give 23 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604253 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-6883df0baedb4a2aa5c1d00ee59d930d |
| Source note | uspto-grants-1997_02 |