Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | N-(2,3-Dihydro-1H-inden-5-yl)acetamide | HCID 583823 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Acetamido-6-bromoindan | HCID 10400034 | 80% |
Reaction Steps
To a solution of 5-acetylaminoindane (53.0 g, 0.30 mol) in glacial acetic acid (1 L) at 10° C. was added dropwise over a period of 1 h a solution of bromine (19.0 mL, 0.37 mol). The mixture was further stirred at 10° C. for 15 min, and was then diluted with water until no more precipitate formed. The precipitate was collected, washed with water and dried under vacuum to give 61 g (80%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05604260 |
|---|
| Source dataset | uspto-grants-1997_02 |
|---|
| ORD ID | ord-70fe2d50acd045a2b75143071b4a28ec |
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| Source note | uspto-grants-1997_02 |
|---|
