Sodium Hydroxide → HCID 74087621, compound

Participants

Reaction Steps

103 mg of 7-[5-benzyloxyimino-2-methyl-8-(2-methylbutyryloxy)-3-oxo-1,2,3,5,6,7,8,8a-octahydro-1-naphthyl]-3-hydroxy-5-oxoheptanoic acid (prepared as described in Example 1b) were dissolved in 2 ml of a 1:1 by volume mixture of dioxane and water. 1.8 ml of a 0.1N aqueous solution of sodium hydroxide were then added dropwise to the solution over a period of 5 minutes at 0° C., after which the solution was stirred for 1 hour at room temperature. At the end of this time, the solution was freeze-dried, to obtain 107 mg of the title compound as a colorless moisture sensitive powder.

Provenance & Evidence