Sodium Hydroxide → HCID 86750377, compound

HRID 1451553Notes

Reaction equation

HRID 1451553 reaction equation
[O:1]1[CH:5]=[C:4]([CH2:6][O:7][N:8]=[C:9]2[CH2:18][CH2:17][CH:16]([O:19][C:20](=[O:25])[CH:21]([CH3:24])[CH2:22][CH3:23])[CH:15]3[C:10]2=[CH:11][C:12](=[O:38])[CH:13]([CH3:37])[CH:14]3[CH2:26][CH2:27][C:28](=[O:36])[CH2:29][CH:30]([OH:35])[CH2:31][C:32]([OH:34])=[O:33])[CH:3]=[N:2]1.O1CCOCC1.[OH-].[Na+:46]>O>[O:1]1[CH:5]=[C:4]([CH2:6][O:7][N:8]=[C:9]2[CH2:18][CH2:17][CH:16]([O:19][C:20](=[O:25])[CH:21]([CH3:24])[CH2:22][CH3:23])[CH:15]3[C:10]2=[CH:11][C:12](=[O:38])[CH:13]([CH3:37])[CH:14]3[CH2:26][CH2:27][C:28](=[O:36])[CH2:29][CH:30]([OH:35])[CH2:31][C:32]([O-:34])=[O:33])[CH:3]=[N:2]1.[Na+:46]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 74002814HCID 74002814, compound

Product 1

HCID 86750377HCID 86750377, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

151 mg of 7-[5-(isoxazol-4-yl)methoxyimino-2-methyl-8-(2-methylbutyryloxy)-3-oxo-1,2,3,5,6,7,8,8a -octahydro-1-naphthyl]-3-hydroxy-5-oxoheptanoic acid (prepared as described in Example 9b) were dissolved in 2.5 ml of a 1:1 by volume. mixture of dioxane and water. 2.7 ml of a 0.1N aqueous solution of sodium hydroxide were then added dropwise over a period of 5 minutes at 0° C. to the solution, and the resulting mixture was stirred for 1 hour at room temperature. At the end of this time, the solution was freeze-dried, to obtain 153 mg of the title compound as a colorless moisture sensitive powder.

Workup

  1. customAt the end of this time, the solution was freeze-dried

Sources & evidence

ORD record
ord-2734bdfe8a194bc9a41168d423edc501
Source dataset
uspto-grants-1997_02
Patent number
US05604256

Reaction notes

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