HCID 10854452, compound → HCID 10566696, compound

HRID 1451629Notes

Reaction equation

HRID 1451629 reaction equation
[CH2:1]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([N+:22]([O-])=O)([CH2:20][OH:21])[CH2:18][OH:19])=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>C(O)C.[C].[Pd]>[NH2:22][C:17]([C:14]1[CH:13]=[CH:12][C:11]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:16][CH:15]=1)([CH2:20][OH:21])[CH2:18][OH:19]

Participants

4

Reactant 1

HCID 10854452HCID 10854452, compound

Product 1

HCID 10566696HCID 10566696, compoundYield 5.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

2-(4-Decylphenyl)-2-nitro-1,3-propanediol (170 mg) was dissolved in ethanol (30 ml) and the mixture was subjected to catalytic reduction in the presence of 5% palladium carbon (40 mg) under hydrogen pressure of 20 arm. After stirring the mixture for 8 hours, the insoluble matters were filtered off and the filtrate was concentrated. The residue was purified by preparative thin layer chromatography (silica gel) to give 8.9 mg of the subject compound.

Workup

  1. filtrationthe insoluble matters were filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by preparative thin layer chromatography (silica gel)

Sources & evidence

ORD record
ord-ade51b343b8b4102861a0a9050d8a420
Source dataset
uspto-grants-1997_02
Patent number
US05604229

Reaction notes

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