HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxy-4-nitrobenzaldehyde → Ethyl 3-hydroxy-4-nitrocinnamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxy-4-nitrobenzaldehyde | HCID 69712 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 3-hydroxy-4-nitrocinnamate | HCID 54189784 | — |
Reaction Steps
To a solution of 3-hydroxy-4-nitrobenzaldehyde (5 g) in toluene (50 ml) was added carbethoxymethylenetriphenylphosphorane (8.96 g), and the mixture was heated under reflux for 2 h. The mixture was then concentrated and the residue was purified by column chromatography eluting with cyclohexane:ethyl acetate (6:4) to give the title compound. (6.2 g) as a solid, m.p. 95°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604237 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-d13dbf9f6aae4890a1b7c108ae1c0aa6 |
| Source note | uspto-grants-1997_02 |