HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-(3-Methoxy-4-nitrophenyl)-3-buten-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Phosphonium, (3-hydroxypropyl)triphenyl-, bromide | HCID 11025793 | — |
| Reactant | 4-(2-Chloroethoxy)-2-methyl-1-nitrobenzene | HCID 19974653 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-(3-Methoxy-4-nitrophenyl)-3-buten-1-ol | HCID 54459577 | — |
Reaction Steps
The Wittig reaction in THF (100 ml) between 3-methoxy-4-nitrobenzaldehyde (1) (2 g) and 3-hydroxypropyltriphenylphosphonium bromide (2) (5.3 g) in presence of a solution of n-butyllithium (1.6M) in hexane (16.5 ml) gave the title compound (2.6 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05604237 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-451678b82fd2420494803018ecd2e808 |
| Source note | uspto-grants-1997_02 |