HCID 10921303, compound → HCID 10880089, compound

Participants

Reaction Steps

A solution of 150 mg (0.9 mmol) of 4-methyl-1H-quinoline-2,5,8-trione and 150 mg (0.79 mmol) of 2-ethylacrolein dimethylhydrazone in dry chloroform (130 ml) was stirred at room temperature for five minutes. After evaporation of the solvent, the residue was purified by silica gel chromatography using ethyl acetate as eluent to yield 29 mg of the starting hydrazone, 64 mg (30%) of 5 and 60 mg of 6-dimethylamino-4-methyl-1H-quinoline-2,5,8-trone.

Provenance & Evidence