HCID 10856574, compound → HCID 19972868, compound

HRID 1451704Notes

Reaction equation

HRID 1451704 reaction equation
[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]2[C:7](=[O:14])[CH:8]=[CH:9][C:10](=[O:13])[C:11]=2[CH:12]=1)[CH3:2].CN(C)[N:18]=[CH:19][C:20]([CH3:22])=[CH2:21]>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]2[C:7](=[O:14])[C:8]3[C:9]([C:10](=[O:13])[C:11]=2[CH:12]=1)=[CH:21][C:20]([CH3:22])=[CH:19][N:18]=3)[CH3:2]

Participants

4

Reactant 2

HCID 10856574HCID 10856574, compoundHCID 542371221,1-Dimethyl-2-(2-methylprop-2-en-1-ylidene)hydrazine

Product 1

HCID 19972868HCID 19972868, compoundYield 45.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A suspension of 3-ethyl-1H-quinoline-2,5,8-trione (200 mg, 0.99 mmol) in chloroform (40 ml) is treated with 145 mg (1.3 mmol) of 2-methylpropenal dimethylhydrazone. The reaction was stirred at room temperature for 5 minutes and evaporated, and the residue was chromatographed on silica gel, eluting with ethyl acetate, to yield 120 mg (45%) of 7.

Workup

  1. customevaporated
  2. customthe residue was chromatographed on silica gel
  3. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-a914a0c9371940e6b4b1a67ad1dc281f
Source dataset
uspto-grants-1997_02
Patent number
US05605905

Reaction notes

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