4,4-Dimethyl-7-ethynyl-1-tetralone → Benzoic acid, 4-((5,6,7,8-tetrahydro-5,5-dimethyl-8-oxo-2-naphthalenyl)ethynyl)-, ethyl ester

Participants

Reaction Steps

Employing the same general procedure as for the preparation of ethyl 4- [(5,6,7,8-tetrahydro-8,8-dimethyl -5-oxonaphth-2-yl)ethynyl]benzoate (Compound 1), 4 g (21.7 mmol) of 7-ethynyl-3,4 -dihydro-4,4 -dimethyl -naphthalen-1(2H)-one (Compound L) was converted into the title compound using 6 g (21.7 mmol) of ethyl 4-iodobenzoate, 5 g (7.2 mmol) of bis (triphenylphosphine) palladium (II) chloride and 1.4 g (7.2 mmol) of cuprous iodide.

Provenance & Evidence