Dimethyl Sulfoxide → HCID 22923382, 화합물

HRID 1451893노트

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HRID 1451893 반응식
Br.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([CH3:13])=[CH:10][CH:11]=2)[C:6](=[O:14])[N:5]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[C:4]1=[O:21].CS([C:26]1[C:31]2[CH:32]=[C:33]([O:38][CH3:39])[C:34]([O:36][CH3:37])=[CH:35][C:30]=2[N:29]=[N:28][N:27]=1)(=O)=O.CS(C)=O>CO>[CH3:39][O:38][C:33]1[C:34]([O:36][CH3:37])=[CH:35][C:30]2[N:29]=[N:28][N:27]=[C:26]([N:18]3[CH2:19][CH2:20][CH:15]([N:5]4[C:6](=[O:14])[C:7]5[C:12](=[CH:11][CH:10]=[C:9]([CH3:13])[CH:8]=5)[N:3]([CH3:2])[C:4]4=[O:21])[CH2:16][CH2:17]3)[C:31]=2[CH:32]=1

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 147138604-Methanesulfonyl-6,7-dimethoxy-1,2,3-benzotriazineHCID 218512221,2,3,4-Tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide2회

생성물 1

HCID 22923382HCID 22923382, 화합물수율 67%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The procedure similar to that described in Example 'was repeated, except that 354.0 mg (1.0 mmol) of 1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxo-3-(4-piperidinyl)quinazoline hydrobromide (Compound v) obtained in Example 41 was used, 4-methanesulfonyl-6,7-dimethoxy-1,2,3-benzotriazine was used in place of 4-chloro-6,7-dimethoxyquinazoline, DMSO was used as a reaction solvent in place of methanol, and the reaction was conducted at room temperature. As a result, 307.6 mg (yield: 67%) of Compound 75 was obtained as white crystals.

후처리

  1. customobtained in Example 41
  2. customwas conducted at room temperature

출처 및 근거

ORD 기록
ord-3b72859a72624cc78320efb68c4fc0ac
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05605900

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