Ethyl 2-fluoropropionate → HCID 19973090, compound

HRID 1451937Notes

Reaction equation

HRID 1451937 reaction equation
[F:1][CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[F:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[C:17](=[O:24])[CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1>>[F:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[C:17]([OH:24])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:2]([F:1])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

3

Reactant 2

HCID 265947Ethyl 2-fluoropropionateHCID 5880801-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Product 1

HCID 19973090HCID 19973090, compound

Procedure

Ethyl 2-fluoropropionate and 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one were treated in the same manner as in Reference Example 7, and the residue thus obtained was purified by a column chromatography (eluant: ethyl acetate/toluene=1/4) to obtain ethyl 3-(2,4-difluorophenyl)-2-fluoro-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyrate (one of the diastereomers).

Workup

  1. customthe residue thus obtained
  2. customwas purified by a column chromatography (eluant: ethyl acetate/toluene=1/4)

Sources & evidence

ORD record
ord-850a4d8803ef41028aa0852776c24aa6
Source dataset
uspto-grants-1997_02
Patent number
US05605921

Reaction notes

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