反应详情

To a stirred solution consisting of 1-(1-amino-1H-pyrrol-2-yl)ethanone (3.88 g) and carbobenzyloxyglycine (6.54 g) in dry DCM (115 ml) was added DCC (6.77 g) at 0° C. under nitrogen. The reaction mixture was allowed to stir at room temperature for 18 hours. The precipitated DCU was removed by filtration and washed with ethyl acetate. The combined filtrates were concentrated to give the crude product. Purification via flash column chromatography (silica gel, 10% EtOAc/hexane) afforded 6.98 g of the product as a solid, m.p. 109°-111° C.

1. customThe precipitated DCU was removed by filtration
2. washwashed with ethyl acetate
3. concentrationThe combined filtrates were concentrated
4. customto give the crude product
5. customPurification via flash column chromatography (silica gel, 10% EtOAc/hexane)