Dimethylformamide → HCID 86746720, compound

Participants

Reaction Steps

A solution of S-(acetamidomethyl)-L-cysteine (2 mmol) 1 in 10 mL of anhydrous dimethylformamide containing 4-dimethylaminopyridine (2 mmol) is cooled in an salt-ice bath to 0°-5° C. To this solution is added previously cooled isobutylchloroformate (2 mmol), and the solution is incubated at this temperature for another 30 minutes. A solution of N-(t-butoxycarbonyl)-L-glutamic acid-γ-butyl ester 2 (2 mmol) in 5 mL of dimethylformamide is added at such a rate that the temperature of the reaction mixture does not exceed 0° C.

Provenance & Evidence