HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 6,7-dihydro-8(5H)-quinolinone oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 6,7-Dihydro-5H-quinoline-8-one | HCID 11744777 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 6,7-dihydro-8(5H)-quinolinone oxime | HCID 135742185 | 79.7% |
Reaction Steps
A solution of 2.22 g of 8-oxo-5,6,7,8-tetrahydroquinoline, 2.1 g of hydroxylamine hydrochloride, and 4.1 g of sodium acetate in 15 mL of 3:1 ethanol-water was heated at 70° C. for 1 h. The reaction mixture was then diluted with water and extracted with dichloromethane. Evaporation of the extracts gave 1.95 g of product which was pure enough by NMR to be used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05606054 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-616f9980b82548c1bbd84bb66d83f319 |
| Source note | uspto-grants-1997_02 |