HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl isocyanate → 3-Chloro-4-isocyanatobenzenesulfonyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl isocyanate | HCID 8110 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Amino-3-chlorobenzenesulfonamide | HCID 1502014 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 3-Chloro-4-isocyanatobenzenesulfonyl isocyanate | HCID 22182825 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
5,7-Dichloro-4-[4-(methylcarbamoyl)-3-chlorobenzenesulfonimide]-1,4-dihydroquinoline-2-carboxylic acid, methyl ester ##STR38## Dissolve 4-amino-3-chlorobenzenesulfonamide (0.96g, 5mmol) in chlorobenzene (10% solution) and distill the mixture to remove any traces of water. Cool to 100° C. and add n-butyl isocyanate (99mg, 1mmol). Heat to reflux and add, by dropwise addition, oxalyl chloride (1.5mL). Purge with nitrogen at 130°-132° C. for 30 minutes and distill to give 3-chloro-4-isocyanatobenzenesulfonyl isocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05606063 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-32d90dac3ffb46b38936df6f2c697a48 |
| Source note | uspto-grants-1997_02 |